Prolotherapy / Regenerative Injection Therapy

Prolotherapy, also known as regenerative injection therapy, is an excellent treatment option for musculoskeletal (MSK) disorders and dysfunction of all types.  Prolotherapy is the process of injecting a solution of dextrose, procaine, and Vitamin B12 into injured tissues. Common areas of treatment include tendons, ligaments, muscle fascia and joint capsules.  The purpose of these injections is to strengthen injured areas by producing new, healthy connective tissue.  In fact, prolotherapy is the only non-surgical treatment proven to rebuild and strengthen connective tissue.  This tissue regneration (or cell proliferation) is mediated by various growth factors.

Used with permission from Ross Hauser, MD. Prolo Your Pain Away! 2007. Caring Medical Regenerative Medicine Clinics.

 Most chronic joint pain is due to a weakness in ligaments and tendons that surround the joint. Prolotherapy corrects this underlying weakness.  It takes, on average, three to six treatments to effectively cure most chronic pain. In the more advanced cases, treatment with PRP (platelet rich plasma) may be needed for optimal results.  We have seen great results in the following conditions:

• ligament and tendon weakness resulting in joint instability or pain
• chronic MSK disorders unresponsive to more conservative treatment
• sports injuries
• Motor vehicle accidents
• falls
• repetitive vigorous spinal manipulation
• osteoarthritis

For a list of studies showing the efficacy of prolotherapy click here

Used with permission from Ross Hauser, MD. Prolo Your Pain Away! 2007. Caring Medical Regenerative Medicine Clinics.

References

Rabago D, et al:  Prolotherapy in primary care practice.  Prim Care.  2010 Mar;37(1):65-80.  http://www.ncbi.nlm.nih.gov/pubmed/20188998 

Topol GA, Reeves KD:  Regenerative injection of elite athletes with career-altering chronic groin pain who fail conservative treatment: a consecutive case series. Am J Phys Med Rehabil.  2008 Nov;87(11):890-902.  http://www.ncbi.nlm.nih.gov/pubmed/18688199

Miller MR, Mathews RS, Reeves KD: Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose.  Pain Physician. 2006 Apr;9(2):115-21.  http://www.ncbi.nlm.nih.gov/pubmed/16703971

Hakala RV: Prolotherapy (proliferation therapy) in the treatment of TMJ.  Cranio.  2005 Oct;23(4):283-8.  http://www.ncbi.nlm.nih.gov/pubmed/16353469

Topol GA, Reeves KD, Hassanein KM: Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain.  Arch Phys Med Rehabil.  2005 Apr;86(4):697-702. http://www.ncbi.nlm.nih.gov/pubmed/15827920

Linetsky FS, Miguel R, Torres F:  Treatment of cervicothoracic pain and cervicogenic headaches with regenerative injection therapy.  Curr Pain Headache Rep.  2004 Feb;8(1):41-8.       http://www.ncbi.nlm.nih.gov/pubmed/14731382

Reeves KD, Hassanein KM: Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Altern Ther Health Med 2003 May-Jun;9(3):58-62.  http://www.ncbi.nlm.nih.gov/pubmed/12776476  
Klein RG, et al: Biochemical injection treatment for discogenic low back pain: a pilot study.  Spine J.  2003 May-Jun;3(3):220-6.  http://www.ncbi.nlm.nih.gov/pubmed/14589203

Reeves KD, Hassanein KM: Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: evidence of clinical efficacy.  J Altern Complement Med. 2000 Aug;6(4):311-20.  http://www.ncbi.nlm.nih.gov/pubmed/10976977
Reeves KD, Hassanein KM: Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med 2000 Mar;6(2):68-74, 77-80. http://www.ncbi.nlm.nih.gov/pubmed/10710805

Ongley MJ, et al:  A new approach to treatment of chronic low back pain. Lancet 2:143-146, 1987.  http://www.ncbi.nlm.nih.gov/pubmed/2439856